HGP-write:

A Grand Challenge

May 10, 2016 | Boston, MA

HGP-write:
Testing Large Genomes in Cells

Hosted by: Jef Boeke, George Church, Andrew Hessel and Nancy J Kelley

May 10, 2016 • Boston, MA
8:30 am – 7:00 pm

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HGP-Write:

Testing Large Genomes in Cells

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Meeting Agenda


8:30 – 9:00 Registration and Continental Breakfast

9:00 – 9:10 Welcome to Harvard Medical School

  • Overview of the Meeting, George Church and Nancy J Kelley

9:10 – 10:00 Overview of Project and Current Synthetic Genomics Environment

  • Overview of HGP-write, Jef Boeke, Andrew Hessel
  • Lessons Learned: Sc 2.0: The Synthetic Yeast Genome Project, Leslie Mitchell, Patrick Cai
  • Lessons Learned: From rEcoli to 1 Million Genomes, George Church

10:00 – 10:50 HGP-write: Presentation/Discussion of 1% Pilot Projects

  • Jef Boeke / Farren Isaacs  |  UltraSafe Cell Line
  • Harris Wang  |  Synthesizing a Prototrophic Human Genome
  • Liam Holt  |  The Seven Signals Toolbox: Enabling HGP-write Cell and Tissue Therapies
  • Nili Ostrov  |  Recoding E.coli to 57 Codons

10:50 – 11:20 Break

11:10 – 12:20 Related Research Areas That Could Complement or Benefit HGP-write

  • Alex Ng  |  Human Organoids, iPS Differentiation
  • Luhan Yang  |  Transplantation
  • Vladimir Larionov  |  Human Artificial Chromosomes
  • Alina Chan  |  De Novo Chromosomes the Shuttle Between Yeast and Mammalian Systems
  • Timothy Lu  |  Microbiome  Engineering
  • Amy Wagers  |  Gene Therapy
  • Dieter Egli  |  Haploid Embyonic Stem Cells

12:20 – 1:40 Panel/Group Discussion | Lunch (provided)

  • Is “HGP-write: Testing Large Genomes in Cells” a wise choice?
  • Moderator: Marc Vidal, Harvard Medical School Department of Genetic
    • Pilar Ossario, University of Wisconsin Madison
    • Debra Methews, Johns Hopkins Berman Institute of Bioethics
    • Scott Fahrenkrug, Recombinetics
    • Nicole Lockhart, National Human Genome Research Institute

1:40 – 2:00 Safety Engineering

  • Farren Isaacs  |  General Introduction
  • Jim Collins  |  Building Genetic Containment

2:00 – 2:30 Scientific Talks on Infrastructure, Technology Development and Technical Challenges

  • Sean Stevens  |  Synthetic Genomics, Inc.
  • Helge Bastian  |  Thermo Fisher Scientific
  • Huimin Zhao  |  Fully Automated Genome-Scale Engineering

2:30 – 3:30 Industry Engagement Panel

  • Moderator: Andrew Hessel  |  Autodesk
    • Emily Leproust  |  Twist Biosciences
    • Kevin Munnelly  |  Gen 9
    • Sandra Glucksmann  |  Editas
    • Brian Zambrowicz  |  Regeneron

3:30 – 4:15 Break

4:15 – 5:15 Regulatory and Bioethical Implications of the 1% Pilot Projects (Panel Discussion)

  • Moderator: Eleonore Pauwels, Wilson Center
    • Jeantine Lunshof  |  Harvard Medical School
    • Pilar Ossorio  |  University of Wisconsin Madison
    • Matthew Porteus  |   Stanford University
    • Barbara Evans  |  University of Houston Law Center
    • Nicole Lockhart  |  National Human Genome Research Institute

5:15 – 5:45 Wrap Up and Next Steps (Nancy J Kelley)

6:00 – 8:00 Evening Cocktails

HGP-write: A Grand Challenge

Tuesday, May 10, 2016 from 8:30 AM to 7:00 PM (EDT)

Harvard Medical School, 77 Avenue Louis Pasteur,
New Research Building (NRB), Seminar Room 350
Longwood Medical Area, Boston, MA 02115