Pilot Projects

GP-write is proceeding in phases according to the initial roadmap (White Paper) to evaluate feasibility and value, similar to other large-scale genome projects such as HGP-read, Encyclopedia of DNA Elements (ENCODE), and the Synthetic Yeast Project (Sc2.0). Each of these earlier projects began with pilot projects that focused on a fraction of the genome, typically about 1%. For GP-write, only those projects that are deemed to provide valuable resources for advanced biomedical research and/or biotechnology development will be chosen.

The Scientific Executive Committee evaluates every pilot project submitted. Both approved projects and those currently under review are briefly described below.

Until the project is fully funded, GP-write is supporting the scientists submitting pilot projects with letters of recommendation. In the future, the goal is to financially support the pilot projects directly. There are two ways to apply for a pilot project: 1) Scientists can apply for funding through their university and GP-write will support the project with a Letter of Recommendation, or 2) scientists can partner with the Center of Excellence to apply for funding.

Please contact info@engineeringbiologycenter.org for more information.

Submit a Pilot Project Proposal

Approved Pilot Projects

Project Lead(s)	Project Title
Jef Boeke, NYU Langone Medical Center George Church, Harvard Medical School	Ultra Safe Cell Line
Pamela Silver, Wyss Institute Jeffrey Way, Wyss Institute John Glass, J. Craig Venter Institute	High-throughput HAC Design to Test Connections Between Gene Expression, Location and Conformation
Liam Holt, NYU Langone Health	The Seven Signals Toolbox: Leveraging Synthetic Biology to Define the Logic of Stem-Cell Programming
Neville Sanjana, New York Genome Center	Precision Human Genome Engineering of Disease-Associated Noncoding Variants
Harris Wang, Columbia University	Synthesizing a Prototrophic Human Genome
Yasunori Aizawa, Tokyo Institute of Technology	Synthetic Screening for Essential Introns and Retroelements in Human Cell and Animals
Matt Maurano, NYU Langone Health	The Dark Matter Project

Proposed Pilot Projects

— Under Review by Scientific Executive Committee —

Project Lead(s)	Project Title
C. Neal Stewart, Jr., University of Tennessee Scott C. Lenaghan, University of Tennessee	Installing "Mini-Symplastomes" in Crops
Tom Ellis, Imperial College London Paul Freemont, Imperial College London	Rational and Combinatorial Refactoring of Recombining Human Chromosomal Clusters
Jake Beal, Raytheon BBN Technologies	Genomic-scale Design Representation with SBOL
Dieter Egli, Columbia University	Stable Haploid Human Pluripotent Stem Cells
Bogumil Karas, Western University, Ontario	Development of a Pipeline for Precision Cloning and Effective Storage of Large Synthetic or Natural Human DNA Fragments
Kenji Tsuge, Kobe University	Long and Precise Genomic DNA Construction Using Bacillus Subtilis
Rosario Isasi, University of Miami Stephan Zuchner, University of Miami	Re-writing Regulation? A Comparative Policy Study of "Natural" vs "Synthetic" Cells, Organoids and Human Genomes
Matthew Chang, NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI) and the Singapore Consortium for Synthetic Biology (SINERGY) Wen Shan Yew, NUS SynCTI and SINERGY Chueh Loo Poh, NUS SynCTI and SINERGY	Winning the Fight Against Diabetes: Singapore to GP-write
Stephan Zuchner, University of Miami Rosario Isasi, University of Miami	An In-Situ Digital Annotation System to Document and Safeguard GP-write Applications
Yaniv Erlich, New York Genome Center	DNA Fountain
Elibio Leopoldo-Rech Filho, EMBRAPA and Nat Inst of S&T, Synthetic Biology Cintia Coelho, University of Brasilia and Nat Inst of S&T, Synthetic Biology James A. Birchler, University of Missouri	Utilization of Recombinases (Serine Integrases) to Regulate Gene Expression